Seprase/FAP BioAssay(TM) ELISA Kit, Human

Seprase/FAP BioAssay(TM) ELISA Kit, Human
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
144037.96 96 tests - -

3 - 19 Werktage*

947,00 €
 
Sandwich ELISA quantitative detection kit for Human Seprase/FAP in cell culture supernates, serum... mehr
Produktinformationen "Seprase/FAP BioAssay(TM) ELISA Kit, Human"
Sandwich ELISA quantitative detection kit for Human Seprase/FAP in cell culture supernates, serum and plasma (heparin, EDTA). FAP (Fibroblast Activation Protein, Alpha) also known as FAPA or SEPRASE, is an inducible cell surface glycoprotein that was originally identified in cultured fibroblasts using monoclonal antibody F19. The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. The FAP gene is mapped on 2q24.2. FAP is most closely related to DPPIV and they share about 50% of their amino acids. FAP is catalytically active as a 170kD dimer and has dipeptidase and gelatinase activity. Its gelatinase activity requires a glycine in P2 position.FAP-alpha shows 48% amino acid identity with dipeptidyl peptidase IV and 30% identity with DPP4-related protein. Northern blot analysis detected a 2.8-kb FAP-alpha mRNA in fibroblasts. Depletion of FAP-expressing cells, which made up only 2% of all tumor cells in established Lewis lung carcinomas, caused rapid hypoxic necrosis of both cancer and stromal cells in immunogenic tumors by a process involving interferon-gamma and tumor necrosis factor-alpha. , Assay Range:, 62.5pg/ml-4000pg/ml, Sensitivity: < 10 pg/ml, Crossreactivity: There is no detectable cross-reactivity with other relevant proteins. Uniprot ID: Q12884, Entrez Gene ID: 2191, Kit Components: 96-well plate pre-coated with anti-Seprase/FAP, Human, Lyophilized recombinant Seprase/FAP, Human standard, 10ng/tube, 2Ea, USB Cat No Kit Component, 143696 Avidin-Biotin-Peroxidase Complex (ABC), 130ul (1:100 dilution), 143697 Sample diluent buffer, 30ml, 143698 Antibody diluent buffer, 12ml, 143699 ABC diluent buffer, 12ml, 143700 TMB color developing agent, 10ml, 143701 TMB stop solution, 10ml, Storage and Handling: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles.
Hersteller: United States Biological
Hersteller-Nr: 144037

Eigenschaften

Anwendung: ELISA
Spezies-Reaktivität: human
Format: Solid Phase

Handhabung & Sicherheit

Lagerung: vT
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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