Rat SMPDL3A (Acid sphingomyelinase-like phosphodiesterase 3a) ELISA Kit

Rat SMPDL3A (Acid sphingomyelinase-like phosphodiesterase 3a) ELISA Kit is a high quality kit for research use only from Assay Genie. The Rat SMPDL3A (Acid sphingomyelinase-like phosphodiesterase 3a) ELISA Kit comes in a 96 Assays format and reacts against Rat samples. We ship this kit on Gel Pack and kits should be stored at 2-8°C Protein Function: Cyclic-nucleotide phosphodiesterase that acts as a negative regulator of innate immunity by mediating degradation of 2',3'-cGAMP, thereby inhibiting the cGAS-STING signaling. Specifically linearizes 2',3'-cGAMP into 2'5'-bond pGpA and further hydrolyzes pGpA to produce GpA. Also has in vitro nucleotide phosphodiesterase activity with nucleoside triphosphates, such as ATP. Has in vitro activity with p-nitrophenyl-TMP. Has lower activity with nucleoside diphosphates, and no activity with nucleoside monophosphates. Has in vitro activity with CDP-choline, giving rise to CMP and phosphocholine. Has in vitro activity with CDP-ethanolamine. Does not have sphingomyelin phosphodiesterase activity [The Uniprot Consortium]