Rat Notch 2 (Notch Homolog 2) ELISA Kit

ELISA Type: Sandwich-Ab. Detection Range: 78.13-5000µg/mL. Sensitivity: 46.88µg/mL. Sample Types: Serum, plasma and other biological fluids. Protein function: Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Positively regulates self-renewal of liver cancer cells. [The UniProt Consortium]