Ran Activation Assay Kit

Configuration-specific monoclonal antibody that recognizes Ran-GTP, but not Ran-GDP. The only available Ran activation assay kit directly measures the level of Ran-GTP. Providing reliable results with consistent reproducibility than other Ran activation assay kits based on certain downstream signaling pathways. Providing shorter experimental time. Could be used to monitor the activation of Ran in cells and in tissues by immunohistochemistry. Protein function: GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. [The UniProt Consortium]