Rac Activation Assay Kit

Configuration-specific monoclonal anti-Rac-GTP antibody based. This monoclonal antibody specifically recognizes Rac-GTP, but not Rac-GDP. Providing shorter experimental time. Providing reliable results with consistent reproducibility than other Rac activation assay kits. Could be used to monitor the activation of Rac in cells and in tissues by immunohistochemistry Protein function: Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. [The UniProt Consortium]