Mouse TNFSF11 - RANKL ELISA Kit

Mouse TNFSF11 - RANKL ELISA Kit
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
KOA0506 1 kit - -

6 - 10 Werktage*

848,00 €
 
Natural and recombinant mouse TNFSF11. There is no detectable cross-reactivity with other... mehr
Produktinformationen "Mouse TNFSF11 - RANKL ELISA Kit"
Natural and recombinant mouse TNFSF11. There is no detectable cross-reactivity with other relevant proteins. Protein function: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts (PubMed:24039232). During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (PubMed:23395171, PubMed:26644563). [The UniProt Consortium]
Schlagworte: Opgl, Tnfsf11
Hersteller: Rockland Immunochemicals
Hersteller-Nr: KOA0506

Eigenschaften

Anwendung: ELISA
Wirt: Mouse
Spezies-Reaktivität: mouse
Immunogen: Expression system for standard: NSO, Immunogen sequence: R72-D316
Format: Solid Phase

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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