Mouse Angiopoietin-1 ELISA Kit

Mouse Angiopoietin-1 ELISA Kit
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Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
KOA0770 1 kit - -

1 - 9 Werktage

673,00 €
 
Natural and recombinant mouse Angiopoietin-1. There is no detectable cross-reactivity with other... mehr
Produktinformationen "Mouse Angiopoietin-1 ELISA Kit"
Natural and recombinant mouse Angiopoietin-1. There is no detectable cross-reactivity with other relevant proteins. Protein function: Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. [The UniProt Consortium]
Schlagworte: Agpt, ANG-1, Angpt1, Angiopoietin-1
Hersteller: Rockland Immunochemicals
Hersteller-Nr: KOA0770

Eigenschaften

Anwendung: ELISA
Wirt: Mouse
Reaktivität: Mouse
Immunogen: Expression system for standard: NSO, Immunogen sequence: H16-F497
Format: Solid Phase

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
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Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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