Human WISP1 - CCN4 ELISA Kit

Natural and recombinant human WISP1. There is no detectable cross-reactivity with other relevant proteins. Protein function: Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan. [The UniProt Consortium]