Human S100A12 ELISA Kit

Human S100A12 ELISA Kit
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Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
KOA0672 1 kit - -

1 - 9 Werktage

613,00 €
 
Natural and recombinant human S100A12. There is no detectable cross-reactivity with other... mehr
Produktinformationen "Human S100A12 ELISA Kit"
Natural and recombinant human S100A12. There is no detectable cross-reactivity with other relevant proteins. Protein function: S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases, MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus. [The UniProt Consortium]
Schlagworte: S100A12
Hersteller: Rockland Immunochemicals
Hersteller-Nr: KOA0672

Eigenschaften

Anwendung: ELISA
Wirt: Human
Reaktivität: Human
Immunogen: Expression system for standard: E.coli, Immunogen sequence: M1-E92
Format: Solid Phase

Datenbank Information

UniProt ID : P80511 | Finde Alternativen
Gene ID GeneID 6283 | Finde Alternativen

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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