Human RBPJ (Recombining binding protein suppressor of hairless) ELISA Kit (HUFI08556)

Human RBPJ (Recombining binding protein suppressor of hairless) ELISA Kit from Assay Genie is a pre-coated immunoassay with a high sensitivity and broad range and has been designed to measure Human RBPJ (Recombining binding protein suppressor of hairless) in serum, plasma & cell culture supernatant samples. The Human RBPJ (Recombining binding protein suppressor of hairless) ELISA Kit accurately measures natural Human RBPJ (Recombining binding protein suppressor of hairless) levels quantified versus standard curves obtained and is based on antibodies raised against a recombinant Human RBPJ (Recombining binding protein suppressor of hairless) peptide. Protein function: Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA (PubMed:21991380). Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (PubMed:23303788). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits. [The UniProt Consortium]