Human NOV - CCN3 ELISA Kit

Human NOV - CCN3 ELISA Kit
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KOA0500 1 kit - -

1 - 9 Werktage

673,00 €
 
Natural and recombinant human NOV. There is no detectable cross-reactivity with other relevant... mehr
Produktinformationen "Human NOV - CCN3 ELISA Kit"
Natural and recombinant human NOV. There is no detectable cross-reactivity with other relevant proteins. Protein function: Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival (PubMed:15181016, PubMed:15611078, PubMed:12695522, PubMed:21344378, PubMed:12050162). Acts by binding to integrins or membrane receptors such as NOTCH1 (PubMed:12695522, PubMed:21344378, PubMed:15611078). Essential regulator of hematopoietic stem and progenitor cell function (PubMed:17463287). Inhibits myogenic differentiation through the activation of Notch-signaling pathway (PubMed:12050162). Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling (PubMed:20139355). Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival (PubMed:12695522). Plays also a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts (PubMed:15611078). Involved in bone regeneration as a negative regulator. Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification (PubMed:21871891). Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion. Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti- inflammatory effects occur secondary to the inhibition of NF- kappaB signaling pathway (PubMed:21063504). Contributes to the control and coordination of inflammatory processes in atherosclerosis. Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement (PubMed:21871891). [The UniProt Consortium]
Schlagworte: NOV, CCN3, NovH, IBP-9, IGFBP-9, CCN family member 3, Protein NOV homolog, IGF-binding protein 9, Insulin-like growth factor-binding protein 9, Nephroblastoma-overexpressed gene protein homolog
Hersteller: Rockland Immunochemicals
Hersteller-Nr: KOA0500

Eigenschaften

Anwendung: ELISA
Wirt: Human
Reaktivität: Human
Immunogen: Expression system for standard: NSO, Immunogen sequence: T32-M357
Format: Solid Phase

Datenbank Information

UniProt ID : P48745 | Finde Alternativen
Gene ID GeneID 4856 | Finde Alternativen

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
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Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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Human CCN3 ELISA Kit Human CCN3 ELISA Kit
805,00 € 644,00 €
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