Human LOXL2 ELISA Kit

Human LOXL2 ELISA Kit
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Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
KOA0838 1 kit - -

1 - 9 Werktage

673,00 €
 
Natural and recombinant human LOXL2. There is no detectable cross-reactivity with other relevant... mehr
Produktinformationen "Human LOXL2 ELISA Kit"
Natural and recombinant human LOXL2. There is no detectable cross-reactivity with other relevant proteins. Protein function: Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E- cadherin, probably by mediating deamination of histone H3. Also involved in E-cadherin repression following hypoxia, a hallmark of epithelial to mesenchymal transition believed to amplify tumor aggressiveness, suggesting that it may play a role in tumor progression. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation. [The UniProt Consortium]
Schlagworte: LOXL2, Lysyl oxidase homolog 2, Lysyl oxidase-like protein 2, Lysyl oxidase-related protein 2, Lysyl oxidase-related protein WS9-14
Hersteller: Rockland Immunochemicals
Hersteller-Nr: KOA0838

Eigenschaften

Anwendung: ELISA
Wirt: Human
Reaktivität: Human
Immunogen: Expression system for standard: NSO, Immunogen sequence: Q26-Q774
Format: Solid Phase

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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