Human LOX-1 - OLR1 ELISA Kit

Human LOX-1 - OLR1 ELISA Kit
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Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
KOA0492 1 kit - -

1 - 9 Werktage

673,00 €
 
Natural and recombinant human LOX-1. There is no detectable cross-reactivity with other relevant... mehr
Produktinformationen "Human LOX-1 - OLR1 ELISA Kit"
Natural and recombinant human LOX-1. There is no detectable cross-reactivity with other relevant proteins. Protein function: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro- oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro- atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram- positive bacteria. [The UniProt Consortium]
Schlagworte: OLR1, CLEC8A
Hersteller: Rockland Immunochemicals
Hersteller-Nr: KOA0492

Eigenschaften

Anwendung: ELISA
Wirt: Human
Reaktivität: Human
Immunogen: Expression system for standard: NSO, Immunogen sequence: S61-Q273
Format: Solid Phase

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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