Human Lipocalin-2 - NGAL ELISA Kit

Human Lipocalin-2 - NGAL ELISA Kit
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KOA0514 1 kit - -

1 - 9 Werktage

728,00 €
 
Natural and recombinant human NGAL. There is no detectable cross-reactivity with other relevant... mehr
Produktinformationen "Human Lipocalin-2 - NGAL ELISA Kit"
Natural and recombinant human NGAL. There is no detectable cross-reactivity with other relevant proteins. Protein function: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. [The UniProt Consortium]
Schlagworte: p25, HNL, NGAL, LCN2, Lipocalin-2, Oncogene 24p3, Siderocalin LCN2, Neutrophil gelatinase-associated lipocalin, 25 kDa alpha-2-microglobulin-related subunit of MMP-9
Hersteller: Rockland Immunochemicals
Hersteller-Nr: KOA0514

Eigenschaften

Anwendung: ELISA
Wirt: Human
Reaktivität: Human
Immunogen: Expression system for standard: NSO, Immunogen sequence: Q21-G198
Format: Solid Phase

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
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Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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