Human ABCG1 (ATP Binding Cassette Transporter G1) CLIA Kit

ELISA Type: CLIA. Sensitivity: 18.75 pg/mL. Range: 31.25--2000 pg/mL. Protein function: Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta- hydroxycholesterol and this transport is coupled to hydrlysis of ATP (PubMed:17408620, PubMed:24576892). The lipid efflux is ALB-dependent (PubMed:16702602). Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta- hydroxycholesterol (PubMed:17408620). [The UniProt Consortium]