KLK7 Fluorogenic Assay Kit

The KLK7 Fluorogenic Assay Kit is designed to measure KLK7 (Kallikrein-7) protease activity for screening and profiling applications. The assay kit comes in a convenient 96-well format, with enough recombinant KLK7, fluorogenic substrate, and assay buffer for 100 enzyme reactions. Figure 1: Illustration of the assay principle. Need us to run inhibitor screens or profile your compounds against KLK7? Check out our Protease Screening and Profiling Services. Kallikrein-7 (KLK7), previously known as SCCE (stratum corneum chymotryptic enzyme), is a member of the kallikrein subfamily of serine proteases, and exhibits chymotrypsin-like activity and participates in the proteolysis of intercellular cohesive structures preceding desquamation, the shedding of the outermost epidermal layer. It has been linked to cancer-related processes, including invasion and metastasis. Elevated expression of the Kallikrein-7 gene is associated with an unfavorable prognosis and the progression of various cancer types. Polymorphisms in this gene may contribute to the development of atopic dermatitis (AD). Kallikrein-7 is thus a multifaceted protease with implications in both normal physiology and disease states.