Anti-IgD (human) Rabbit Monoclonal Antibody (Clone RM123)

Immunoglobulin D (IgD) is a member of the immunoglobulin superfamily of glycoproteins that functions as a B cell antigen receptor (BCR) and has roles in adaptive immunity. Human IgD is composed of two Igdelta heavy chains of approximately 50 kDa each and two Ig? or Iglambda light chains of approximately 25 kDa each. It is expressed on the surface of antigen-naïve mature B cells, which are found in germinal centers and peripheral blood, as well as certain subsets of circulating memory B cells. IgD levels increase during B cell maturation and are regulated by alternative splicing of an mRNA transcript that is common to the µ and delta heavy chains of IgM and IgD, respectively. Upon antigen activation, IgD can undergo class switch recombination to the immunoglobulin isotypes IgA, IgE, or IgG, each of which has a distinct effector function. IgD can also be produced from IgM by class switch recombination, leading to the generation of IgD-secreting plasma cells that have roles in mucosal immunity. IgD binds to basophil and mast cell lines, as well as the respiratory pathogens M. catarrhalis and H. influenzae, in vitro. Serum IgD levels are increased in patients with a variety of conditions, including leprosy, tuberculosis, malaria, or Hodgkin's lymphoma and is a hallmark of hyperimmunoglobulinemia D syndrome (HIDS), an autoinflammatory condition characterized by febrile episodes. Cayman's IgD (human) Rabbit Monoclonal Antibody (Clone RM123) can be used for ELISA.Synonyms: Immunoglobulin D. Immunogen: Human IgD. Clone Designation: RM123. Formulation: (Request formulation change), 100 µg of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: ELISA. Cross Reactivity: (+) IgD, (-) Human IgG, (-) Human IgM, (-) Human IGA, (-) Human IgE.