Anti-Human NRARP Antibody Pair

Product Description: NOTCH regulated ankyrin repeat protein (NRARP) is a small protein containing two ankyrin repeats that functions as a downstream effector and negative feedback regulator of Notch signaling. It plays a role in various developmental processes and is involved in the regulation of cell proliferation, differentiation, and apoptosis. NRARP stabilizes LEF1 protein, a key transcription factor in the Wnt signaling pathway, by blocking its ubiquitination. It is also involved in angiogenesis, acting downstream of Notch at branch points to regulate vascular density. NRARP expression has been found to be upregulated in several types of cancer, including non-small cell lung cancer (NSCLC), thyroid cancer, and breast cancer. High NRARP expression has been associated with poor prognosis in NSCLC patients and may serve as a potential biomarker for cancer progression. Downregulation of NRARP has shown antitumor activities in thyroid cancer cells. Protein Function: Downstream effector of Notch signaling. Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737). Involved in angiogenesis acting downstream of Notch at branch points to regulate vascular density. Proposed to integrate endothelial Notch and Wnt signaling to control stalk cell proliferation and to stablilize new endothelial connections during angiogenesis (PubMed:19154719). During somitogenesis involved in maintenance of proper somite segmentation and proper numbers of somites and vertebrae. Required for proper anterior-posterior somite patterning. Proposed to function in a negative feedback loop to destabilize Notch 1 intracellular domain (NICD) and down-regulate the Notch signal, preventing expansion of the Notch signal into the anterior somite domain (By similarity) [The Uniprot Consortium]