Anti-Human MMP9 Antibody Pair

Product Description: Matrix metalloproteinase-9 (MMP-9) is a zinc-dependent endopeptidase that plays crucial roles in both physiological and pathological tissue remodeling. It degrades extracellular matrix proteins and activates cytokines and chemokines, regulating inflammation, fibrosis, and immune responses. MMP-9 is involved in various cardiovascular diseases, including hypertension, atherosclerosis, and myocardial infarction. In neurodegenerative disorders like Parkinson's disease, elevated MMP-9 levels are associated with cognitive impairment and may contribute to neuroinflammation and dopaminergic neuronal death. MMP-9 also plays a role in respiratory viral infections, with increased expression observed in influenza, SARS-CoV-2, and respiratory syncytial virus infections. While MMP-9 is essential for normal physiological processes, its dysregulation can exacerbate disease progression. As such, MMP-9 has emerged as a potential biomarker and therapeutic target for various pathologies. Protein Function: Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration (PubMed:12879005, PubMed:1480034, PubMed:2551898). Could play a role in bone osteoclastic resorption (By similarity). Cleaves KiSS1 at a Gly-, -Leu bond (PubMed:12879005). Cleaves NINJ1 to generate the Secreted ninjurin-1 form (PubMed:32883094). Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (PubMed:1480034). Degrades fibronectin but not laminin or Pz-peptide [The Uniprot Consortium]