Anti-Human ZBTB17 Antibody Pair

Product Description: Zinc finger and BTB domain-containing protein 17 (ZBTB17), also known as Miz-1, is a transcription factor characterized by its BTB/POZ domain and multiple zinc finger motifs, which facilitate its role in DNA binding and protein-protein interactions. ZBTB17 is involved in regulating gene expression during various biological processes, including lymphocyte development and cell cycle progression. It plays a crucial role in T cell differentiation by modulating IL-7 signaling and influencing the expression of genes associated with lymphopoiesis. Dysregulation of ZBTB17 has been linked to several diseases, particularly immune disorders and cancers. For instance, mutations or altered expression of ZBTB17 can lead to impaired T cell development, contributing to autoimmune diseases. Additionally, its role in regulating oncogenes suggests that ZBTB17 may act as a tumor suppressor, thus, its loss of function is associated with the progression of certain malignancies. Protein Function: Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription, this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1 (PubMed:25245946) [The Uniprot Consortium]