Anti-Human TERF1 Antibody Pair

Product Description: Telomeric repeat binding factor 1 (TERF1), also known as TRF1, is a crucial protein involved in the maintenance of telomeres, the protective caps at the ends of chromosomes. It binds to the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length by acting as an inhibitor of telomerase, limiting the elongation of individual telomeres. TERF1 is part of the Shelterin complex, which includes other proteins such as TRF2, Rap1, POT1, TIN2, and TPP1, and plays a role in the regulation of the mitotic spindle. The protein contains a MYB-type helix-turn-helix DNA-binding domain and a TRF-homology domain, which are essential for its function. Dysregulation of TERF1 has been implicated in various diseases, including cancer, where altered telomere length can lead to genomic instability. Protein Function: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends, without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways [The Uniprot Consortium]