Anti-Human TAF5L Antibody Pair

Product Description: TATA-box binding protein associated factor 5 like (TAF5L) is a WD-repeat protein that functions as a key component of the PCAF (p300/CBP-associated factor) histone acetylase complex, which acetylates histones in a nucleosomal context to regulate chromatin structure and gene transcription. Structurally similar to the histone-like TAF5, TAF5L facilitates transcription initiation by promoting the recruitment of transcription factors such as TFIID and modifying general transcription factors to enable assembly of the transcriptional machinery. It acts as a transcriptional coactivator and is essential for myogenic differentiation and embryonic stem cell gene expression programs through epigenetic regulation. Disease associations include Heinz Body Anemia, suggesting a role in hematological conditions. Protein Function: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex (Probable). With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state (By similarity) [The Uniprot Consortium]