Anti-Human STX7 Antibody Pair

Product Description: Syntaxin-7 (STX7) is a member of the syntaxin family of proteins, which are integral components of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex involved in membrane fusion processes. STX7 is primarily localized to endosomal membranes and plays a crucial role in mediating vesicle trafficking and fusion within the endosomal-lysosomal pathway. Its function is essential for the recycling of synaptic vesicles and the delivery of cargo to lysosomes. Dysregulation or mutations in STX7 have been associated with several diseases, including Hermansky-Pudlak syndrome, characterized by oculocutaneous albinism and bleeding disorders due to impaired lysosomal function. Additionally, STX7 has been implicated in neurodegenerative diseases, such as Alzheimer's disease, where its dysfunction may contribute to amyloid-beta accumulation. Protein Function: May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes [The Uniprot Consortium]