Anti-Human SLITRK6 Antibody Pair

Product Description: SLIT and NTRK like family member 6 (SLITRK6) is a neuronal transmembrane protein encoded by the SLITRK6 gene, predominantly expressed in the central nervous system, retina, and inner ear. As part of the SLITRK family, it features leucine-rich repeat (LRR) domains in its extracellular region and shares homology with Slit proteins, known for axon guidance. Structurally, SLITRK6 is a type I membrane protein with an extracellular LRR domain, a transmembrane region, and a cytoplasmic tail potentially involved in intracellular signaling. It regulates neurite outgrowth, synaptic connectivity, and cell adhesion, crucial for sensory system development. Pathogenic mutations in SLITRK6 are linked to autosomal dominant nonsyndromic high myopia (MYP25), a severe form of nearsightedness, and hearing impairment, likely due to its role in retinal and cochlear circuit formation. Protein Function: Regulator of neurite outgrowth required for normal hearing and vision [The Uniprot Consortium]