Anti-Human SEMA5A Antibody Pair

Product Description: Semaphorin 5A (SEMA5A) is a transmembrane protein that functions as a bifunctional axonal guidance cue, with attractive effects mediated by heparan sulfate proteoglycans and inhibitory effects via chondroitin sulfate proteoglycans. It plays crucial roles in neuronal and vascular development, regulating axon growth and synapse formation. SEMA5A contains a sema domain and seven thrombospondin type-1 repeats, which are important for its interactions with proteoglycans. The protein is expressed in various tissues, including the developing nervous system, and acts through receptors like plexin B3. SEMA5A has been implicated in several neurological disorders, most notably autism spectrum disorder (ASD), where it has been identified as a susceptibility gene. Additionally, alterations in SEMA5A expression have been associated with Cri-du-Chat syndrome and certain cancers, suggesting its potential involvement in diverse pathological processes. Protein Function: Bifunctional axonal guidance cue regulated by sulfated proteoglycans, attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis [The Uniprot Consortium]