Anti-Human RTN4RL2 Antibody Pair

Product Description: Reticulon 4 receptor like 2 (RTN4RL2) is a cell surface receptor that plays a role in postnatal brain development and neurite outgrowth inhibition. It is a glycosylphosphatidylinositol (GPI)-anchored protein with leucine-rich repeat domains. RTN4RL2 contributes to normal axon migration across the brain midline and corpus callosum formation. It interacts with myelin-associated glycoprotein (MAG) and is involved in protecting motoneurons against apoptosis. The protein also participates in restricting dendritic spine and synapse numbers during brain development. RTN4RL2 activates Rho signaling and influences actin cytoskeleton reorganization. In terms of disease relevance, altered RTN4RL2 expression has been associated with hearing impairment, as RTN4RL2 knockout mice showed increased sound thresholds and impaired hearing. Additionally, changes in RTN4RL2 methylation have been linked to environmental exposures like bisphenol A, which may have implications for developmental disorders. Protein Function: Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system. Protects motoneurons against apoptosis, protection against apoptosis is probably mediated by MAG (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200) [The Uniprot Consortium]