Anti-Human pTau205 Antibody Pair

Product Description: Phosphorylated tau at position 205 (p-tau205) has emerged as a significant biomarker for tau pathology in Alzheimer's disease (AD). Recent studies indicate that p-tau205 levels increase progressively across the AD continuum, correlating strongly with neurofibrillary tangles rather than amyloid plaques, which are typically associated with earlier stages of the disease. This biomarker demonstrates robust associations with tau-PET imaging, particularly in advanced Braak stages of tau pathology, suggesting its potential utility in staging and monitoring disease progression. CSF p-tau205 is also linked to cognitive decline, highlighting its relevance in clinical settings for diagnosing and tracking AD. Its specificity for tau pathology positions it as a promising alternative to traditional imaging methods in both research and clinical trials aimed at developing AD therapies. Protein Function: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization [The Uniprot Consortium]