Anti-Human POMP Antibody Pair

Product Description: Proteasome maturation protein (POMP) is an essential chaperone that orchestrates the biogenesis of the 20S proteasome core complex, a central component of the cellular protein degradation machinery. POMP localizes to the endoplasmic reticulum (ER), where it binds to alpha1-7 rings of the assembling proteasome, recruits beta-subunits in a stepwise manner, and mediates the association of precursor complexes with the ER membrane, thereby coordinating the assembly and maturation process to ensure efficient formation of functional proteasomes. The degradation of POMP itself is tightly regulated by a dual-checking mechanism, with the alpha5 subunit sensing POMP degradation to trigger the release of other assembly chaperones, thus safeguarding the fidelity of proteasome maturation. Defects in POMP function or expression can impair proteasome assembly, leading to reduced proteolytic capacity and contributing to diseases characterized by protein aggregation and impaired protein homeostasis, such as certain autoinflammatory syndromes and age-related disorders. Protein Function: Molecular chaperone essential for the assembly of standard proteasomes and immunoproteasomes. Degraded after completion of proteasome maturation. Mediates the association of 20S preproteasome with the endoplasmic reticulum [The Uniprot Consortium]