Anti-Human OSMR Antibody Pair

Product Description: Oncostatin M receptor (OSMR) is a type I cytokine receptor that forms heterodimeric complexes with gp130 or IL-31RA to mediate signaling by oncostatin M (OSM) and interleukin-31, respectively. The OSMR protein is widely expressed in non-hematopoietic cells and plays important roles in various biological processes, including inflammation, hematopoiesis, and bone metabolism. It activates multiple signaling pathways, such as JAK/STAT, MAPK, and PI3K, upon ligand binding. Structurally, OSMR contains extracellular immunoglobulin-like and fibronectin type III-like domains, a transmembrane region, and an intracellular domain with phosphorylation sites. Mutations in the OSMR gene are associated with primary localized cutaneous amyloidosis. Additionally, OSMR signaling has been implicated in various pathological conditions, including cancer progression, cardiovascular diseases, and inflammatory disorders. Protein Function: Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events [The Uniprot Consortium]