Anti-Human MVK Antibody Pair

Product Description: Mevalonate kinase (MVK) is an essential enzyme in the mevalonate pathway, which is crucial for cholesterol synthesis and the production of isoprenoids. Specifically, MVK catalyzes the conversion of mevalonic acid to 5-phosphomevalonate, marking the second step in this metabolic pathway. The enzyme is ubiquitously expressed, with significant levels found in leukocytes and skin keratinocytes. MVK plays a vital role in various cellular functions, including cell growth, differentiation, and the maintenance of the cytoskeleton. Mutations in the MVK can lead to mevalonate kinase deficiency, resulting in conditions such as hyperimmunoglobulinemia D syndrome (HIDS) and mevalonic aciduria (MVA). These disorders are characterized by recurrent fever episodes, developmental delays, and other systemic symptoms due to impaired enzyme activity and subsequent accumulation of mevalonic acid. Protein Function: Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis (PubMed:11278915, PubMed:18302342, PubMed:9325256, PubMed:9392419) [The Uniprot Consortium]