Anti-Human MBP Antibody Pair

Product Description: Myelin Basic Protein (MBP) is a key structural component of the myelin sheath that insulates axons in the central nervous system. It plays a crucial role in the formation and maintenance of compact myelin, facilitating efficient nerve signal conduction. MBP exists in multiple isoforms arising from alternative splicing, with the 18.5 kDa isoform being the most abundant in adult human myelin. Disruption or degradation of MBP is associated with demyelination and neurodegeneration in diseases like multiple sclerosis (MS). Genetic variants in the MBP gene can influence the clinical course of MS, with certain variants predicting higher relapse rates and disability progression, potentially through mechanisms involving microRNA regulation. Additionally, MBP fragments released during myelin breakdown can trigger further myelin disassembly and serve as autoantigens driving the autoimmune response in MS. Protein Function: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation [The Uniprot Consortium]