Anti-Human MAGED1 Antibody Pair

Product Description: MAGE family member D1 (MAGED1) is a ubiquitously expressed protein that plays diverse roles in cellular processes including differentiation, apoptosis, cell cycle regulation, tumorigenesis, and adipogenesis. It contains three functional domains: the DNA polymerase subunit domain (DNAPIII), the interspersed hexa-peptide repeat domain (IRD), and the MAGE homology domain (MHD). MAGED1 interacts with various proteins to regulate their expressions, such as PCNA in esophageal tumorigenesis, and proteins involved in apoptosis signaling pathways. Notably, its deficiency has been shown to attenuate Parkinson's disease progression by upregulating the Akt signaling pathway and downregulating the mTOR signaling pathway. MAGED1's involvement in neuronal apoptosis and its interaction with proteins like cAMP response element-binding protein highlight its role in synaptic transmission and learning and memory formation. Protein Function: Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as BMAL1 and NFIL3, induced, or NR1D1, repressed [The Uniprot Consortium]