Anti-Human LRRC4C Antibody Pair

Product Description: Leucine rich repeat containing 4C (LRRC4C), also known as NGL-1, is a type I transmembrane protein predominantly expressed in the brain, especially in the cerebral cortex (frontal, parietal, occipital lobes), with moderate expression in regions like the hippocampus and amygdala. Structurally, it contains nine leucine-rich repeats flanked by N- and C-terminal LRR domains and an Ig-like C2-type domain in its extracellular region, and a cytoplasmic tail with a PDZ-binding motif, facilitating interactions with postsynaptic density proteins. LRRC4C functions as a synaptic adhesion molecule binding specifically to netrin-G1, promoting neurite outgrowth and synapse formation, particularly in thalamocortical axons, thus playing a critical role in synaptic organization and plasticity in the developing brain. Disease associations include developmental and epileptic encephalopathy and autism spectrum disorder, with evidence suggesting that disruptions in LRRC4C contribute to neurodevelopmental disorders by impairing synaptic connectivity and neural circuit formation. Protein Function: May promote neurite outgrowth of developing thalamic neurons [The Uniprot Consortium]