Anti-Human LRIG3 Antibody Pair

Product Description: Leucine rich repeats and immunoglobulin like domains 3 (LRIG3) is a single-pass transmembrane protein that belongs to the LRIG family. It contains a putative signal peptide, leucine-rich repeat domains, immunoglobulin-like domains, a transmembrane domain, and a cytoplasmic tail. LRIG3 is primarily localized in the cell membrane and Golgi apparatus, with some punctate distribution in the cytosol. It is expressed in various tissues, including the brain, inner ear, and craniofacial regions during embryonic development. LRIG3 plays a role in modulating FGF and Wnt signaling pathways, and it can interact with and regulate FGFR1 levels. In terms of disease associations, LRIG3 has been implicated in cancer progression, particularly in gliomas. It may function as a tumor suppressor by inhibiting cell proliferation, survival, and invasion through negative regulation of the EGFR signaling pathway. Protein Function: May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity) [The Uniprot Consortium]