Anti-Human KIRREL3 Antibody Pair

Product Description: Kin of IRRE-like protein 3 (KIRREL3) is a member of the immunoglobulin superfamily, functioning primarily as a cell-adhesion molecule that plays a crucial role in synapse formation and neuronal connectivity during brain development. KIRREL3 is characterized by its single-pass transmembrane structure, containing five extracellular immunoglobulin-like domains and an intracellular PDZ-binding motif, which facilitates homophilic interactions between adjacent neurons. Dysregulation or mutations in the KIRREL3 gene have been linked to several neurodevelopmental disorders, including autism spectrum disorders and intellectual disabilities, where variants can impair synaptic function and connectivity. Research has shown that KIRREL3 is essential for the formation of specific synapses in the hippocampus, particularly those connecting dentate gyrus neurons with GABAergic neurons. Protein Function: Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation. Required for the coalescence of vomeronasal sensory neuron axons. May be involved in the hematopoietic supportive capacity of stroma cells, the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells [The Uniprot Consortium]