Anti-Human IRAKM Antibody Pair

Product Description: Interleukin 1 receptor associated kinase 3 (IRAK3), also known as IRAK-M, is a pseudokinase that plays a critical role in modulating inflammation and immune responses. It is primarily expressed in monocytes and macrophages and is involved in the regulation of Toll-like receptor (TLR) signaling pathways. IRAK3 inhibits the dissociation of IRAK1 or IRAK2 from myddosome complexes, thereby downregulating NF-kappaB activation and reducing the production of inflammatory cytokines such as TNF-alpha and IL-6. IRAK3 is associated with endotoxin tolerance and sepsis, where its upregulation is linked to immunosuppression and worse clinical outcomes. Studies have shown that IRAK3 deficiency leads to enhanced sensitivity to TLR agonists and increased production of proinflammatory cytokines, highlighting its role as a negative regulator of inflammation. Protein Function: Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors (PubMed:10383454, PubMed:29686383). Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity). Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells (PubMed:29686383) [The Uniprot Consortium]