Anti-Human Interferon gamma Receptor 1 Antibody Pair

Product Description: Interferon gamma receptor 1 (IFNGR1), also known as CD119, is a protein encoded by the IFNGR1 gene in humans. It is the ligand-binding chain (alpha) of the heterodimeric gamma interferon receptor, which is crucial for the signaling of interferon-gamma (IFN-gamma). IFNGR1 interacts with IFN-gamma and, together with IFNGR2, forms a receptor complex that activates the JAK/STAT signaling pathway, leading to antiviral, proapoptotic, and antiproliferation activities. Mutations in the IFNGR1 gene can lead to extreme susceptibility to mycobacterial infections, such as familial disseminated atypical mycobacterial infection, and are associated with susceptibility to Helicobacter pylori infection. The deregulation of IFNGR1 expression has also been implicated in the progression of lung adenocarcinoma, affecting IFN-gamma signaling and antiviral responses. Protein Function: Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (PubMed:20015550). Associates with transmembrane accessory factor IFNGR2 to form a functional receptor (PubMed:10986460, PubMed:2971451, PubMed:7615558, PubMed:7617032, PubMed:7673114). Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription (PubMed:28883123). STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1 (By similarity) [The Uniprot Consortium]