Anti-Human Integrin alpha-2 Antibody Pair

Product Description: Integrin alpha-2 (ITGA2) is a transmembrane protein that plays a vital role in cell adhesion and signaling by interacting with the extracellular matrix, primarily collagen. It is part of the integrin family and is crucial for various biological processes, including cell migration, proliferation, and differentiation. ITGA2 is expressed in several tissues, including platelets and various cancer types, where it influences tumor progression and metastasis. Dysregulation of ITGA2 has been implicated in multiple diseases, particularly cancers such as breast cancer, colorectal cancer, and gliomas. In breast cancer, for instance, high levels of ITGA2 expression are associated with increased tumor aggressiveness and poor patient prognosis. Moreover, alterations in ITGA2 expression can impact angiogenesis, further contributing to tumor development. Protein Function: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix , (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A , (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8 [The Uniprot Consortium]