Anti-Human IL3 Antibody Pair

Product Description: Interleukin-3 (IL-3) is a cytokine primarily produced by activated T cells, playing a pivotal role in the immune system by regulating the proliferation and differentiation of various blood cell types. It acts as a multi-lineage growth factor, stimulating hematopoietic stem cells to differentiate into myeloid progenitor cells and promoting the survival of monocyte/macrophage progenitors, which are crucial for immune responses against pathogens. IL-3 also influences the inflammatory response, and its dysregulation has been implicated in various diseases, including hematological malignancies and autoimmune disorders. The signaling pathways activated by IL-3, particularly through its receptor, involve the JAK2/STAT5 pathway, which is essential for gene expression regulation and cell survival. Understanding IL-3's functions and its relationship with disease can provide insights into potential therapeutic targets for immune-related conditions and cancers. Protein Function: Cytokine secreted predominantly by activated T-lymphocytes as well as mast cells and osteoblastic cells that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells (PubMed:2556442). Also stimulates mature basophils, eosinophils, and monocytes to become functionally activated (PubMed:10779277, PubMed:32889153). In addition, plays an important role in neural cell proliferation and survival (PubMed:23226269). Participates as well in bone homeostasis and inhibits osteoclast differentiation by preventing NF-kappa-B nuclear translocation and activation (PubMed:12816992). Mechanistically, exerts its biological effects through a receptor composed of IL3RA subunit and a signal transducing subunit IL3RB (PubMed:29374162). Receptor stimulation results in the rapid activation of JAK2 kinase activity leading to STAT5-mediated transcriptional program (By similarity). Alternatively, contributes to cell survival under oxidative stress in non-hematopoietic systems by activating pathways mediated by PI3K/AKT and ERK (PubMed:27862234) [The Uniprot Consortium]