Anti-Human FTCD Antibody Pair

Product Description: FTCD (Formimidoyltransferase Cyclodeaminase) is an enzyme involved in the metabolism of histidine and folate production. It plays a crucial role as a tumor suppressor in hepatocellular carcinoma (HCC). Downregulation of FTCD expression, often caused by DNA methylation, is strongly associated with HCC progression, larger tumor size, vascular invasion, advanced tumor stage, and poor survival. FTCD deletion promotes lipid accumulation and malignant transformation in HCC mouse models. Clinically, lower FTCD levels correlate with higher HCC risk in cirrhotic patients. Mutations in FTCD can also cause glutamate formiminotransferase deficiency, a rare disorder affecting physical and mental development, with a severe form characterized by profound intellectual disability and megaloblastic anemia. Protein Function: Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool , Binds and promotes bundling of vimentin filaments originating from the Golgi [The Uniprot Consortium]