Anti-Human DSC2 Antibody Pair

Product Description: Desmocollin 2 (DSC2) is a calcium-dependent glycoprotein and a member of the cadherin superfamily, primarily functioning as a key component of desmosomes-specialized cell-cell junctions that provide mechanical strength and stability to tissues by linking adjacent cells together. Structurally, DSC2 contains five N-terminal extracellular domains, a transmembrane domain, and a C-terminal cytoplasmic tail, enabling it to interact with desmoglein family members and plakoglobin, and it undergoes posttranslational modifications such as N-glycosylation and O-mannosylation. DSC2 is ubiquitously expressed in desmosomal tissues like skin epithelia and is the only desmocollin isoform present in cardiac muscle, where it localizes to intercalated discs and is essential for maintaining cardiac tissue integrity. Mutations in the DSC2 gene disrupt desmosome structure and function, leading to impaired cell adhesion and are causally linked to arrhythmogenic right ventricular cardiomyopathy and other disorders affecting the heart, skin, and hair. Protein Function: A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:33596089). Promotes timely incorporation of DSG2 into desmosome intercellular junctions and promotes interaction of desmosome cell junctions with intermediate filament cytokeratin, via modulation of DSP phosphorylation (PubMed:33596089). Plays an important role in desmosome-mediated maintenance of intestinal epithelial cell intercellular adhesion strength and barrier function (PubMed:33596089). Positively regulates wound healing of intestinal mucosa via promotion of epithelial cell migration, and also plays a role in mechanotransduction of force between intestinal epithelial cells and extracellular matrix (PubMed:31967937). May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. May promote p38MAPK signaling activation that facilitates keratinocyte migration (By similarity) [The Uniprot Consortium]