Anti-Human CRTAM Antibody Pair

Product Description: Cytotoxic and regulatory T cell molecule (CRTAM), also known as CD355, is a transmembrane protein of the immunoglobulin superfamily, comprising 393 amino acids with two extracellular immunoglobulin-like domains (IgV and IgC) and a cytoplasmic PDZ-binding motif. CRTAM is predominantly expressed on activated CD8+ T cells, natural killer T (NKT) cells, NK cells, and a subset of CD4+ T cells, where it functions as an adhesion molecule facilitating cell-cell interactions, particularly through binding to its ligand Necl2 on dendritic cells. This interaction is crucial for T cell activation and the production of cytokines such as IFNgamma, IL-17, and IL-22, and it enhances the cytotoxic activity of NK cells against tumors. CRTAM has been implicated in several disease contexts, including inflammation, asthma, malignant mesothelioma, and certain cancers, where its role in promoting pro-inflammatory cytokine production and modulating immune responses may influence disease progression and immunopathology. Protein Function: Mediates heterophilic cell-cell adhesion which regulates the activation, differentiation and tissue retention of various T-cell subsets (By similarity). Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and IFNG/interferon-gamma secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952). Regulates CD8+ T-cell proliferation in response to T-cell receptor (TCR) activation (By similarity). Appears to be dispensable for CD8+ T-cell-mediated cytotoxicity (By similarity). Interaction with SCRIB promotes the late phase of cellular polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG, IL17 and IL22 production (By similarity). By interacting with CADM1 on CD8+ dendritic cells, regulates the retention of activated CD8+ T-cells within the draining lymph node (By similarity). Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity). Interaction with CADM1 promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity) [The Uniprot Consortium]