Anti-Human CLSTN2 Antibody Pair

Product Description: Calsyntenin-2 (CLSTN2), also known as alcadein-gamma, is a neuronal cell surface protein that plays a critical role in synaptic function and cognitive processes. It is part of the calsyntenin family, which is involved in synapse development and maintenance. CLSTN2 is particularly important for the formation of inhibitory synapses, as its deficiency leads to a reduction in parvalbumin interneurons in the hippocampus and cortex, which are crucial for balanced neural activity. Dysregulation of CLSTN2 has been associated with various neurodevelopmental disorders and cognitive impairments. Studies have shown that mutations or deletions in the CLSTN2 gene can result in deficits in spatial learning and memory, as observed in mouse models. Additionally, genetic variations in CLSTN2 have been linked to human cognitive performance, particularly in episodic memory tasks. Protein Function: Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate synapse formation, and which is involved in learning and memory (By similarity). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane (By similarity) [The Uniprot Consortium]