Anti-Human CHST1 Antibody Pair

Product Description: Carbohydrate sulfotransferase 1 (CHST1) is an enzyme encoded by the CHST1 gene in humans. It belongs to the keratin sulfotransferase family and is crucial for the sulfation of keratan sulfate proteoglycans, such as lumican and keratocan, which are major components of the cornea and play a significant role in corneal transparency. The enzyme specifically catalyzes the sulfation of keratan sulfate, with no activity towards chondroitin. CHST1 is expressed in various tissues, including the brain, cornea, and skeletal muscle. Undersulfated keratan sulfate is associated with macular corneal dystrophy, highlighting the importance of CHST1 in maintaining proper keratan sulfate function. Protein Function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of internal galactose (Gal) residues of keratan. Cooperates with B4GALT4 and B3GNT7 glycosyltransferases and CHST6 sulfotransferase to construct and elongate disulfated disaccharide unit [->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer (PubMed:10642612, PubMed:17690104, PubMed:9405439). Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer (PubMed:9405439). Involved in biosynthesis of phosphacan, a major keratan sulfate proteoglycan in the developing brain (By similarity). Involved in biosynthesis of 6-sulfoGalbeta-containing O-linked glycans in high endothelial venules of lymph nodes. May act in a synergistic manner with CHST4 to generate sialyl 6',6-disulfo Lewis X motif, a recognition determinant for immune cell receptors implicated in leukocyte trafficking (PubMed:10330415). Catalyzes sulfation of N-acetyllactosamine (LacNAc) oligosaccharides with highest efficiency for sialylated LacNAc structures (PubMed:10642612) [The Uniprot Consortium]