Anti-Human CD59 Antibody Pair

Product Description: CD59 molecule (CD59 blood group) (CD59), also known as MAC-inhibitory protein (MAC-IP), membrane inhibitor of reactive lysis (MIRL), or protectin, is a glycoprotein that plays a crucial role in protecting human cells from complement-mediated lysis. It is encoded by the CD59 gene and is expressed in all organs and almost all cell types. CD59 functions by inhibiting the formation of the membrane attack complex (MAC) by binding to complement proteins C8 and C9, preventing pore formation and cell lysis. Mutations affecting the glycophosphatidylinositol (GPI) anchor that attaches CD59 to host cells can lead to diseases such as paroxysmal nocturnal hemoglobinuria. Additionally, viruses like HIV and human cytomegalovirus incorporate host cell CD59 into their viral envelopes to evade complement-mediated lysis. Protein Function: Potent inhibitor of the complement membrane attack complex (MAC) action, which protects human cells from damage during complement activation (PubMed:11882685, PubMed:1698710, PubMed:2475111, PubMed:2475570, PubMed:2606909, PubMed:9053451). Acts by binding to the beta-haipins of C8 (C8A and C8B) components of the assembling MAC, forming an intermolecular beta-sheet that prevents incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (PubMed:11882685, PubMed:1698710, PubMed:36797260) , The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit complement membrane attack complex (MAC) assembly on cell membranes [The Uniprot Consortium]