Anti-Human CD38 Antibody Pair

Product Description: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) is a multifunctional enzyme that plays a pivotal role in calcium signaling and immune response regulation. It catalyzes the synthesis of cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP) from NAD+, which are crucial second messengers for calcium mobilization in cells. CD38 is expressed on various immune cells, including T and B lymphocytes, where it acts as both an enzyme and a receptor, influencing cell activation and proliferation. Dysregulation of CD38 has been implicated in several diseases, such as leukemias and myelomas, where its expression is often elevated and associated with tumor progression. Additionally, CD38 is linked to autoimmune diseases and metabolic disorders, including type 2 diabetes, where it may affect insulin secretion and sensitivity. Protein Function: Synthesizes cyclic ADP-ribose (cADPR), a second messenger for glucose-induced insulin secretion (PubMed:7961800, PubMed:8253715). Synthesizes the Ca(2+) mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), from 2'-phospho-cADPR and nicotinic acid, as well as from NADP(+) and nicotinic acid. At both pH 5.0 and pH 7.4 preferentially transforms 2'-phospho-cADPR into NAADP(+), while preferentially cleaving NADP(+) to cADPR and ADPRP rather than into NADDP(+) (PubMed:16690024). Has cADPR hydrolase activity (PubMed:7961800, PubMed:8253715) [The Uniprot Consortium]