Anti-Human CD300LB Antibody Pair

Product Description: CD300 molecule like family member b (CD300LB) is a nonclassical activating receptor of the immunoglobulin (Ig) superfamily primarily expressed on myeloid cells. It is part of the CD300 family, which modulates a diverse array of immune cell processes through paired activating and inhibitory receptor functions. Unlike CD300a and CD300f, which have long cytoplasmic tails with ITIMs (immunoreceptor tyrosine-based inhibition motifs), CD300LB and other non-ITIM-containing CD300 receptors have short cytoplasmic tails and associate with adaptor proteins such as DAP12, DAP10, and the Fc receptor gamma chain. CD300LB has been identified as a lipopolysaccharide-recognizing receptor that regulates TLR4 signaling, indicating its role in immune responses. The protein's expression is widespread across various tissues, including the brain, lymph nodes, and bone marrow. This suggests that CD300LB plays a significant role in modulating immune functions and may be involved in the pathogenesis of several disease states. Protein Function: Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2 [The Uniprot Consortium]