Anti-Human CCDC15 Antibody Pair

Product Description: Coiled-coil domain containing 15 (CCDC15) is a protein that plays a crucial role in the structural integrity and function of centrioles, which are essential for cellular processes such as cilia formation and centrosome organization. CCDC15 localizes to the inner scaffold of centrioles, where it interacts with other scaffold proteins to regulate centriole length and stability. Disruption of CCDC15 function has been linked to various diseases, most notably neurodevelopmental disorders characterized by cataracts, highlighting its importance in developmental processes and cellular signaling pathways like Hedgehog signaling. The protein's coiled-coil structure facilitates interactions with multiple partners, contributing to its regulatory functions in centriole architecture. Studies have shown that loss of CCDC15 leads to defective ciliogenesis and compromised cellular responses . Protein Function: Plays an important role in primary cilium assembly, maintenance, and length regulation. Interacts with centriole inner scaffold proteins to promote proper centriole size and integrity and assembly of functional cilia. Required for the recruitment of both the inner scaffold protein POC1B and the distal SFI1/CETN2 complex to centrioles [The Uniprot Consortium]