Anti-Human BACH1 Antibody Pair

Product Description: Transcription regulator protein BACH1 (BACH1) is a member of the Cap 'n' Collar and basic region leucine zipper (CNC-bZIP) family of transcription factors. It contains a Broad-complex, Tramtrack, and Bric-à-brac (BTB) domain, six cysteine-proline (CP) motifs, and a basic leucine zipper (bZIP) domain, which enable it to bind DNA and form heterodimers with small Maf proteins[1][2]. BACH1 primarily functions as a transcriptional repressor, regulating the expression of genes involved in oxidative stress response, heme homeostasis, cell cycle, and immunity. Dysregulation of BACH1 has been implicated in various diseases, including cancer, where it can promote tumor progression and metastasis by altering the expression of genes related to angiogenesis, epithelial-mesenchymal transition, and stemness. Additionally, BACH1 has been linked to neurodegenerative disorders and autoimmune diseases. Protein Function: Transcriptional regulator that acts as a repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordinating transcription activation and repression by MAFK (By similarity). Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway (PubMed:24035498) [The Uniprot Consortium]