Anti-Human ADGRB1 Antibody Pair

Product Description: Adhesion G protein-coupled receptor B1 (ADGRB1), also known as brain-specific angiogenesis inhibitor 1 (BAI1), is a receptor involved in various physiological processes, including angiogenesis, synaptogenesis, and macrophage function. Structurally, it features multiple thrombospondin type 1 repeats and a GAIN domain that facilitates autoproteolysis, crucial for its signaling functions. Mutations in ADGRB1 are linked to diseases such as lung cancer and neurological disorders, highlighting its role in tumor suppression and neural development. Additionally, ADGRB1 mediates the engulfment of apoptotic cells by binding to phosphatidylserine, showcasing its importance in immune responses. Protein Function: Phosphatidylserine receptor which enhances the engulfment of apoptotic cells (PubMed:24509909). Also mediates the binding and engulfment of Gram-negative bacteria (PubMed:26838550). Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity (PubMed:26838550). In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells (PubMed:24509909). Promotes myoblast fusion (By similarity). Activates the Rho pathway in a G-protein-dependent manner (PubMed:23782696). Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity (By similarity). Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1 (By similarity). Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma (PubMed:11875720) , Inhibits angiogenesis in a CD36-dependent manner , Inhibits angiogenesis [The Uniprot Consortium]